He made his television debut on KBS Gag Concert in 2002 with a segment called "Doremi Trio" (도레미 트리오). In this segment, he sang excerpts of K-pop songs with comedic punches at the end. He then joined various segments of MBC's Sunday Sunday Night and Exclamation! and KBS2's Imagination Plus and a host and performer. In 2005, he became a regular host on MBC's Infinite Challenge.
In November 2015, Jeong's agency, FNC Entertainment, announced that he was taking a break from all activities due to his anxiety disorder. At the time, he was a cast member or host on several television shows, including Infinite Challenge, Weekly Idol, and Please Take Care of My Refrigerator. he officially left the cast of Infinite Challenge in July 2016.
He returned as the co-host of Weekly Idol in October 2016, ending his 11-month break from television activities. In March 2018, both Jeong and Defconn left Weekly Idol. In May, they became hosts of the variety show Idol Room.
He married comedy writer Han Yu-ra on September 13, 2009.] They have two children, twin daughters, who were born on December 11, 2012.